I don't think our anti-satellite munitions are up to the task of destroying an entire core stage booster. IIRC they're kinetic-only and not able to really "destroy" much more than a small or medium satellite. Punching a hole through the empty fuel tank of a spent booster doesn't accomplish anything.
If it's just a fuel tank with an engine at this shallow of an entry, then there's no possible way anything significant will be hitting the ground.