Well I tried a new round this year. A bolt action 25.06 using a 117 grain Hornady. No problem with stopping the deer but my son said it was too much bullet and caused a mess inside the deer. I have used a 35 Remington regularly with good success and have thought about using my .243 safe queen but it is too pretty and engraved. I also hunted with a 7mm-08 and a 300 Blackout. Would be interested in what caliber you use and do you have any significant spoilage with that caliber. All my shots are 100 to 200 yards, though I did get deer at 40 feet.