I understand that the Vortex mounts on the rear site location of the slide. What I haven't seen is that you get cowitnessed iron sights for the same $479. The only guns I've seen with cowitnessed sights include about $500 or more of machining and supressor sights attached to the firearm.
I would not trust a firearm with red dot only for defensive use. Cowitnessing is a MUST.
I know the Vortex is battery operated only right now, but there is a version of the Trijicon RMR that is Tritium and Fiber Optics. That would take the battiers out of it. However, I'm not sure what they'd charge to replace the tritium when it quits glowing.