Cubby, why is it so difficult? I don't have a lot of striking hand to hand training, and zero knife hand to hand training, but the little I have is based on kick boxing and I find a reverse grip on a knife most comfortable, so i figured the karambit made sense. again I'm learning every day!
The one big issue when considering a self defense knife ( and one many overlook) is defensebility in court. If you ever had to use it, to cut a person many blades will work, however knives like the spyderco civilian, Karambits, auto matic knives, Hawkbills, can easily be used in court to curicify you. As much as I love the wave feature, I still am cautious with knives that have it as the wave feature was designed for the SEALS.
Knives that from spyderco with the hole design, can be deployed very quickly with practice by grabing the hole and flicking the wrist. , Blade heavy knives like the spyderco 's police knives, enduras, Microtechs socom knives are also very easy to deploy with an inertia type opening. I am a big fan of the Delica, Calypso Jounior, and Para millitary, and the Chinese Lum folder, are great lightweight knives from SPyderco.