There used to be at least one solid, practical reason for them back when BP was the only propellant: They acted as channels to direct a good deal of the fouling away from the face of the cylinder. This helped to slow the accumulation of fouling there so that more rounds could be fired before functioning started to be impeded. They also reduced the mass of the cylinder, which translates into less inertia and reduces the amount of force needed to cause it to rotate.
With the advent of DA revolvers the latter reason became more important, as is helped a lot to effectively increase the mechanical advantages in the mechanism and increased its efficiency while reducing both the force needed to cycle it and the amount of stress placed on several small, critical components, especially the hand, cylinder ratchet and locking bolt.
This helped yield a reduced DA pull effort and longer service life.
I also thought it might be a throw back from the Colt peacemaker days ...when the cylinder had to be rotated and each empty had to be ejected one at a time.