I completely understand this. I'm a huge fan of 357, and got out of 45 (well, I wasn't really THAT deep into it) because I couldn't justify two pricey calibers when it made more sense (to me) to concentrate on one. The wheel guns won this minor battle.This is one of the reasons that I got rid of both my Shield .45 and Ruger SR 1911 .45 (which churchmouse called me out on) is b/c since they weren't going to be a carry gun for me, I wasn't willing to spend 5 times more for running 300 rounds at the range with a .45 instead of my beloved 22LR since I enjoy it as much as anything.
My younger brother had (past-tense) a Sig 238 in 380 that he thought was the bomb. While it was a nifty looking little package that was easily pocket carried, I never warmed up to that gun. Even with 380 being a more mild round than 9mm, that little 238 was hard for me to keep from being jumpy... my long spidery fingers could never quite get the right grip on it, and I didn't enjoy shooting it at all. Boy did he talk up the benefits of 380 to me 'til he was winded, but I could never buy into it. Good on others if it's a round they are partial to, but the cost of it over 9mm for what I considered a ballistically weaker round made it impossible for me to give it a any sort of serious consideration.
As for 22LR, especially now that it's easily acquired again, dang if it's not a TON of affordable fun. I have a little Ruger SR22 that I bought (I think) the second year they were out. Mine has the threaded barrel option. If you haven't given the SR22 a look, it's worth at least holding one. I like that it's hammer-fired (as is the case with the rest of my smallish collection), so if it doesn't go "bang" the first time, another squeeze of the trigger normally sets it off on the rare occasion this happens.