How long of a barrel? If I wanted to go <10", I would lean towards the .300blk simply due to the cartridge's efficiency in shorter barrels. With 16" barrels or an 18" 5.56 barrel and light-for-caliber bullets, the .300blk seems to hold an advantage to 300yds or so for medium game. OTOH, it's my understanding that the 75gr & 77gr bullets seem to bring the practical advantage back to the 5.56 as the range increases.
If you reload and are good with an 18" or longer barrel, I think the 6.5 Grendel looses little (if any) in terms of short-range performance, has good mid- to long-range ballistics for the case length, and has some excellent bullet options.
If you reload and are good with an 18" or longer barrel, I think the 6.5 Grendel looses little (if any) in terms of short-range performance, has good mid- to long-range ballistics for the case length, and has some excellent bullet options.