i focus on 50 yards.....kind of a good average to begin and adjust to other distances....
50 yards is a great place to start. The difference between 25 and 50 for a .22 is nothing. Either way, at least your shooting!!
I zero in at 25 yards because at 50 you will be about .75" high and at 100 yds you will be approximately 1" low. So from 0 to 100 yards you will be within 1 inch.
Are you sure you're talking about .22?
I commonly see more like 8 MOA drop between 25 and 100.