Vacuum sealer shrinks things like clothing.Mine is a 40L bag with lots of crap in it. It weighs roughly 20-25 LBS currently... which I'll admit is a pain in the ass to lug around. Trauma kit, 2 survival space blankets, hammock w/ bug net, life straw, 2400 Calorie food bar (x2), 100ft paracord, water purification tablets, mountain house meal (x2), zip ties, lighter w/ electrical tape combo, water proof matches w/ cotton dipped in vasoline, extra socks, multipurpose knife set, box of 9mm, handcuffs, empty trash bags (x2), flashlight, spare batteries, collapsible cooking set, sunglasses, ear pro, bug spray, deodorant, etc.
I also have a soft armor vest, boots, layers of clothing and additional meals, portable charger, and other items that could be used if staying around my vehicle... if I needed to bug out they could potentially be shouldered around in a separate bag.
I also water proofed everything in baggies... my best advise would be to prepare your kit like it's going to rain every day.