There are two handgun calibers. The .45 ACP, designed to slay America's blood-raged hordes of enemies on the battlefield and the .357 Magnum, designed to kill Tommy gun wielding gangsters hiding behind the doors of their Dusenbergs.
Everything else is an also ran. Fine for lady's parlor games and the annoying of small game for leisure, but not for a manly man's manly needs in a weapon.