I've shot two deer with a handgun, .44 mag at close range. On one I missed the heart but the lungs were both hit. The second deer I dropped it with the first shot but had to shoot it again. Both deer took a while to die, and that really turned me off to handgun hunting. I wish you a better experience. I would like to hear how it goes for you, I might try it again if I thought my experiences were not the norm. I like hitting them with a 12 ga slug or muzzleloader, they die very quickly.