The caliber of shotguns is measured in terms of gauge (U.S.) or bore (U.K.). The gauge number is determined by the number of solid spheres of a diameter equal to the inside diameter of the barrel that could be made from a pound of lead. So a 10 gauge shotgun nominally should have an inside diameter equal to that of a sphere made from one-tenth of a pound of lead. By far the most common gauges are 12 (0.729 in, 18.5 mm diameter) and 20 (0.614 in, 15.6 mm), although .410 (= 36), 32, 28, 24, 16, and 10 (19.7 mm) gauge and 9 mm (.355 in.) and .22 (5.5mm) rimfire calibres have also been produced (although 10, 12, 16, 20, 28, .410, and .22 are the only legal hunting gauges/calibers in most U.S. states). To further complicate matters, typical handgun chamberings such as 9 mm Parabellum, .45 ACP, .38 Special/.357 Magnum, .44 Special/.44 Magnum, and .45 Colt and others bearing a "shot" load have been brought to market by CCI/Speer--either crimped in or in a plastic casing replacing the bullet. These are not generally considered "shot shells" by shotgun users, and the patterning performance is questionable since they are fired through rifled barrels. Thompson/Center makes special pistol barrels in .38/.357, .44 and .45 Colt that have "straight rifled" chokes in them to reduce the spin of the shot column and produce better patterns, but they are still suitable only for pest control at very short ranges. Larger gauges, too powerful to shoulder, have been built but were generally affixed to small boats and referred to as punt guns. These were used for commercial water fowl hunting, to kill large numbers of birds resting on the water. Although relatively rare, single and double derringers have also been produced that are capable of firing either .45 (Long) Colt or .410 shotgun shells from the same chamber; they are commonly known as 'snake guns', and are popular among some outdoorsmen in the South and Southwest regions of the United States. There are also some revolvers, such as the Taurus Judge, that are capable of shooting the .45LC/.410 rounds; but as with derringers, these are handguns that shoot .410 shotgun shells, and are not necessarily considered shotguns themselves.
Its a wierd measurement, it actually refers to the number of lead balls that size that equal a pound, ie it takes 12 balls the diameter of a 12 guage barrel to weigh one pound