Is it possible to use a can for a larger caliber on a smaller caliber (say 45ACP & 9mm)? Not ideal I realize, but maybe practical?
What is meant by a can?
I have a followup question, is the effectiveness of the suppressor affected by caliber in general?
Is a 45acp suppressor quieter because the round is slower?
"Quieter" than what?
Initially, common sense would dictate that a .45 can would be more effective at what it is intended to do than, say a 9mm can because the .45ACP is a heavy, slow projectile. This is not the case. A .45 is pretty difficult to suppress to the level of a suppressed subsonic 9mm. One big reason is the bore diameter. A larger bore leads to more gasses excaping through it, which equals a louder report. This reason is exactly why a suppressed subsonic.22lr round is pretty much 'Hollywood' quiet. Small, slow projectile, and small bore diameter coupled with a relatively low volume of propellent gasses equals a very efficient (read:quiet) package. Suppressors are a tricky beast and to really know and understand them, you just have to use them. You'll get a variety of answers to your questions depending on who you ask, but as I said before, you just have to experiment with the darn things to learn for yourself. In a nutshell, the answer to your question of: is the effectiveness of the suppressor affected by caliber in general? is YES, but not for the reasons you may have initially thought.