Not saying its better, Just don't understand hunting coyotes from 300-400yds !? Most coyotes we kill are way less then 100yds. Most are coming to the call and are shotgun close. We have one guy with a shotgun and one with a rifle. We use a fox pro and a wiggler. They see the wiggler and focus in on it. But then again we are not doing a lot of night hunting. We mainly hunt mornings , mid day and evenings .Considering the 243 has more velocity and energy than a 22-250, I wonder why the 22-250 would be better?